After years of seeing her granddaughter in jeans that were too long and too loose, Karen Bowersox searched hard for brands that would work for the girl and others with Down syndrome. None existed.

"There was nothing that fit them," said Bowersox, of suburban Cleveland. Convinced that "people with disabilities are a forgotten population in the world," Bowersox, an entrepreneur with "no clue" about the garment industry, spent four years creating Downs Designs pants, "shaped and sized" for children and adults with Down syndrome. All of the brand's pull-on jeans, khakis and black slacks have an elastic waist, belt loops, shorter proportioned legs and a mock fly to simplify dressing. The Downs line is part of her larger NBZ Apparel International, which stands for No Buttons/Zipperless. Read More